EndoSure Endometriosis Blog

ENDOSURE, INC. Announces Development of @Home Version of Award Winning ENDOSURE TEST

Tue, 17 Mar 2026 00:39:21 GMT

The technology, developed by the 3CPM Company, was one of four finalists to win the National Institute of Health’s RADx Tech ACT ENDO Challenge.

ENDOSURE, INC. is delighted to announce the development of the @HOME version of the award winning ENDOSURE TEST.

The technology, developed by the 3CPM Company, was one of four finalists to win the National Institute of Health’s RADx Tech ACT ENDO Challenge. Once released, the @HOME TEST will make it possible for women to know if they have endometriosis in the comfort of their own homes.

ENDOSURE, INC. holds the exclusive license to globally market this groundbreaking technology.

“ 3CPM developed, and continues to develop, as well as manufactures the ENDOSURE TEST for us,” said Mr. Carlos Babini, CEO of ENDOSURE, INC. “The positive impact of what our current TEST offers women globally is irrefutable. This new technological advancement promises to be even more life altering. We thank the RADx Tech ACT ENDO Challenge Team along with 3CPM for helping improve lives of women everywhere.”

The ENDOSURE TEST, is the only non-invasive, 30-minute, highly accurate TEST capable of detecting endometriosis in women of any age at any stage, and is currently available in hospitals, clinics, and physicians' offices in select regions of the world (Canada, Brazil, the Middle East, and Europe).

With the development of an at home test, testing will no longer be limited to the clinical environment.

“When we are finished, never again will a 10-year-old with dysmenorrhea have to endure the inconvenience and embarrassment of visiting a gynecologist office to discover if endometriosis is causing her intense painful menstruation,” stated Dr. Mark Noar, inventor of the technology and CEO of 3CPM Company. "Instead, she will use the home ENDOSURE TEST in the comfort of her home with her mother by her side and then share the TEST result with her healthcare provider to determine next steps."

The RADx Tech ACT ENDO Challenge was designed to accelerate the development of innovative, non-invasive diagnostic solutions for endometriosis and reduce the nearly 10-year wait women experience before ever receiving a diagnosis. The Challenge was sponsored by the National Institutes of Health (NIH) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and National Institute of Biomedical Imaging and Bioengineering (NIBIB).

About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. For more information, visit https://www.nichd.nih.gov .

Please join us in celebrating 3CPM Company's significant achievement!

3CPM Granted Award from National Institutes of Health RADx Tech ACT ENDO Challenge

Tue, 07 Oct 2025 14:06:14 GMT

3CPM, the company responsible for helping develop the non-invasive ENDOSURE TEST for endometriosis, has received the midterm award in the National Institutes of Health (NIH) RADx Tech ACT ENDO Challenge to further develop our Tier-1 technology for at-home endometriosis diagnosis.

This is a distinctive honor to be one of four finalists in the competition, which ends February 2026. The RADx Tech ACT ENDO Challenge was designed to accelerate the development of innovative, non-invasive diagnostic solutions for endometriosis to facilitate earlier detection of this often-debilitating disease which often presents in non-pelvic areas of the anatomy, such as the brain, thoracic cavity, spine as well as anywhere in the anatomy.

Laparoscopic surgery, largely the standard method of diagnosing endometriosis, is limited because it focuses only on looking inside the abdominal and pelvic cavity. Moreover, it is used primarily to identify only the most advanced stages of the disease, contributing to the delay along with disease progression. ACT ENDO aims to promote new solutions to make earlier diagnosis more accessible, regardless stage of disease in order to reduce the nearly10-year wait women experience before receiving proper diagnosis.

As the only non-invasive, 30-minute, highly accurate test capable of detecting endometriosis at any stage and any location in the body, the ENDOSURE TEST gives healthcare providers earlier insights into the complexities of endometriosis, paving the way for more targeted therapies, post treatment evaluation of therapy, and improved quality of life for millions, while creating a world where no woman has to wait nearly a decade before receiving a diagnosis.

The 3CPM Company has a strategic alliance with ENDOSURE, INC. providing ongoing research and development of the ENDOSURE TEST.

“Kudos, to the NIH for recognizing the need to minimize delay and kudos to Dr. Mark Noar and the 3CPM Company for their achievement to date,” said Mr. Carlos Babini, CEO of ENDOSURE, INC. “We are delighted to report that where the technology is currently used, outcome data, as well as patient and clinician response has been extremely positive. Our mission is to do all we can to help the 1 in 10 women who suffer from this terrible disease with ongoing, compelling research and development.”

Currently, over 200 million women globally are afflicted with endometriosis and bear the many burdens associated with the disease.

Dr. Mark Noar, inventor of the technology and CEO of 3CPM Company states, “Clinicians who offer the ENDOSURE TEST tell me it is a major advancement which enables them to definitively diagnose endometriosis and adenomyosis, further allowing the initiation of treatment at early stages and helping to prevent advancement. The opinion is growing that the technology is in fact, a truly ‘generational’ addition to the FemHealth space. We are appreciative and humbled by this award which will certainly help us move ahead toward future iterations of the TEST. We continue to collaborate with ENDOSURE and do our part on the R&D side to make the many benefits of the ENDOSURE TEST available to more women everywhere.”

Please join us in celebrating this significant achievement and in our efforts to make the ENDOSURE TEST available to women and clinicians around the world.

ENDOSURE TEST Declared a Revolutionary Diagnostic Tool in the Battle against Endometriosis

Thu, 07 Aug 2025 14:00:00 GMT

The ENDOSURE TEST was recently featured in a prominent medical blog written by Mr. Nicholas Morris of Rapid Access Gynaecology, based in London.

The article gives an excellent overview of the history of endometriosis, beginning with its dark history as a presumed psychological condition to its modern-day clinical description as a chronic, physical medical condition. With the invention of the Tier-1 ENDOSURE TEST in 2022, Mr. Morris acknowledges the TEST has ushered in what he describes as “a new chapter in the diagnosis of endometriosis.”

As the only non-invasive, highly accurate, 30-minute, Tier-1 test for endometriosis, the ENDOSURE TEST empowers physicians to detect endometriosis at its earliest stages and offer targeted, personalized therapy to their patients. It effectively shortens the diagnostic timeline from an average of 8.6 years to less than an hour. The TEST empowers patients too, because they no longer must wait nearly a decade before ever knowing what is wrong, offering hope to any woman at any age afflicted with this horrible disease.

Read Mr. Morris’ full article here:

The Wonders of Endosure: A Novel Diagnostic Tool for Endometriosis | Rapid Access Gynaecology

If you think you have endometriosis, talk to your healthcare provider.

Learn more about the ENDOSURE TEST .

Undiagnosed Endometriosis: The Hidden Risk of Pregnancy Complications

lhird@endosure.com (Leah Hird) — Thu, 10 Jul 2025 13:00:03 GMT

Women with endometriosis are known to have substantially higher pregnancy and postpartum complications, yet many are unaware of the hidden danger.

Endometriosis is a chronic inflammatory condition, affecting at least 1 in 10 women worldwide. Debilitating pain and heavy menstrual flow are commonly associated symptoms. However, an even more important consequence of this condition is the increased risk of pregnancy complications.

Pregnant women with undiagnosed or asymptomatic endometriosis often show little to no warning signs of the condition until serious complications develop. Without a Tier 1 noninvasive tool to detect endometriosis early, they may not be able to take the preventative steps necessary to protect themselves or their unborn child.

Fortunately, this paradigm has shifted with the introduction of the only Tier 1 noninvasive, 30-minute, highly accurate diagnostic tool, the ENDOSURE TEST .

The Alarming Connection Between Endometriosis and Pregnancy Complications

In 2015, a BBC News article highlighted a groundbreaking study conducted on nearly 15,000 women in Scotland. The study shed light on the significant risks endometriosis poses during pregnancy.

The research revealed women with endometriosis have a 76% greater chance of miscarriage, 26% higher risk of premature birth, and a 40% greater likelihood of requiring a cesarean section (C-section) compared to women without the disease. [1]

Women with endometriosis have a 76% greater chance of miscarriage, 26% higher risk of premature birth, and a 40% greater likelihood of requiring a cesarean section (C-section).

More recently, research published in 2023 and 2024 also found that women with endometriosis are at a greater risk of developing preeclampsia, a life-threatening pregnancy complication characterized by high blood pressure and potential organ damage. [2,3]

Preeclampsia accounts for 2% to 8% of all pregnancy-related complications worldwide, contributing to over 50,000 maternal deaths and more than 500,000 fetal deaths annually. [4] These staggering numbers stress the urgent need to increase awareness of the risk of preeclampsia in women with endometriosis.

Even more so, these studies highlight the critical need for diagnostic tools that can detect endometriosis in women who do not know they have the disease.

The Challenge of Asymptomatic Endometriosis

One of the greatest obstacles in addressing the risk of pregnancy complications is the prevalence of asymptomatic endometriosis, often referred to as “silent endometriosis.”

Silent endometriosis presents little to no noticeable symptoms. Yet, it can contribute to the same pregnancy risks as symptomatic cases. The absence of telltale signs like chronic pelvic pain or irregular periods means it often remains undiagnosed until pregnancy complications occur, or fertility challenges come to light.

This is why early diagnosis is so important. It can give women the advantage of time. An early diagnosis gives women the opportunity to make informed decisions about their reproductive health and reduce the risk of pregnancy complications through proactive, targeted care.

How Diagnostic Testing for Endo Can Help Prevent Pregnancy Complications

With the introduction of the ENDOSURE TEST in 2022 as the first Tier 1 diagnostic test for endometriosis equips medical providers with the means to detect endometriosis at any stage and any location in the body – even in asymptomatic cases – in just 30 minutes.

An early diagnosis gives women the opportunity to make informed decisions about their reproductive health and reduce the risk of pregnancy complications.

Through the TEST, every woman, regardless of age, disease location, or pregnancy status, is offered the opportunity to collaborate with her provider about the necessary steps to protect her health and that of her unborn child from the potentially devastating consequences of undiagnosed endometriosis.

Raising Awareness: A Call to Action

The increased risks of pregnancy complications in women with endometriosis cannot be understated. The disease’s impact on miscarriage, preterm birth, C-sections, and preeclampsia highlights the urgent need for greater awareness, earlier detection, and improved medical interventions.

Women of reproductive age, particularly those planning to conceive, should be educated about the potential risks of endometriosis, even if they do not experience symptoms. Medical providers should discuss endometriosis with patients, especially those with a family history.

Women who suspect they may have endometriosis or are concerned about their reproductive health should not hesitate to advocate for themselves. Here are some ways to do that:

Seek Specialized Care. Consult with a gynecologist or reproductive health specialist for a thorough evaluation.

Monitor Symptoms. Keep a detailed record of any unusual pelvic pain, irregular periods, or other potential signs of endometriosis to share with a healthcare provider.

Ask for the ENDOSURE TEST. Even in the absence of symptoms, factors such as a family history of fertility challenges or pregnancy complications may increase the risk of endometriosis. The easy to perform ENDOSURE TEST can detect endometriosis at any stage, and anywhere in the body, regardless of symptoms.

Stay Informed. New research and advancements in technology continue to deepen our understanding of this condition. Staying updated on the latest in endometriosis diagnosis and treatment can help women make better informed decisions and take control of their health.

Conclusion

If you or someone you know is planning a pregnancy or suspects they may have endometriosis, don’t wait to seek answers. Speak with a healthcare provider, explore your options, and advocate for your health.

Through the ENDOSURE TEST, we aim to contribute to the WHO 2023-2030 Roadmap to Prevention of Postpartum Hemorrhage (PPH), making it a successful reality for women around the world.

Together, we can shine a light on this hidden danger and pave the way for safer, healthier pregnancies.

Learn More about the ENDOSURE TEST

If you’d like to learn more about the ENDOSURE TEST, we invite you to reach out . We welcome any questions you may have.

References:

1. Gallagher, James. Endometriosis “Risks Miscarriage.” BBC News. 2015 Jun 15. Accessed 2025 Jun 23. https://www.bbc.com/news/health-33115478 .

2. Vendittelli F, Barasinski C, Rivière O, Bourdel N, Fritel X. Endometriosis and risk of adverse pregnancy outcomes: a retrospective multicenter cohort study. Fertil Steril. 2024 Jul 31:S0015-0282(24)00633-2. doi: 10.1016/j.fertnstert.2024.07.037. Epub ahead of print. PMID: 39089610.

3. Drummond K, Danesh NM, Arseneault S, et al. Association between Endometriosis and Risk of Preeclampsia in Women Who Conceived Spontaneously: A Systematic Review and Meta-analysis. J Minim Invasive Gynecol . 2023;30(2):91-99. doi: 10.1016/j.jmig.2022.11.008

4. Karrar, S.; Martingano, D.; and Hong, P. Preeclampsia. StatPearls. Updated 2024 Feb 25. Accessed 2025 Feb 28. https://www.ncbi.nlm.nih.gov/books/NBK570611/

5. World Health Organization. (n.d.). Preeclampsia and eclampsia statistics.

Adolescent Endometriosis: Why It's Underdiagnosed and How You Can Advocate for Timely Diagnosis

lhird@endosure.com (Leah Hird) — Thu, 12 Jun 2025 17:16:41 GMT

The earliest signs of endometriosis often present much earlier than adulthood.

Perhaps the most easily overlooked demographic of women affected by endometriosis is adolescent women. Painful periods are far too easily dismissed as a normal part of growing up, invariably leading to the mistaken and damaging belief that this terrible disease only affects adult women. However, research confirms the earliest signs of endometriosis often appear during adolescence. [1]

Early detection efforts in young women have posed significant challenges, largely due to a lack of education and limitations in Tier 1 diagnostic testing . Historically, medical providers have had to rely on laparoscopic surgery, a high-risk, invasive procedure that most are understandably reluctant to perform on young patients.

The good news is that advancements in noninvasive technology have shifted this entire paradigm. Providers now have a Tier 1 diagnostic test that detects endometriosis at its earliest stages. This offers both adolescent women and their parents hope for a future no longer crippled by undiagnosed pain.

Knowing how to identify the warning signs of endometriosis and how to advocate for a timely diagnosis can help you and your teen access the personalized care they deserve.

Why Is Endometriosis Underdiagnosed in Adolescent Women?

Endometriosis is underdiagnosed in adolescent women for a few key reasons.

Lack of Education

Many medical providers are unaware of how prevalent the disease is among this age group, believing it primarily affects adult women. Research shows this is not the case. For instance, a 2023 study examining the prevalence of adolescent endometriosis revealed symptoms were “notably high” in younger women: [1]

Nearly two-thirds of adult women reported initial onset of symptoms before age 20.
Twenty-one percent had significant pain before age 15.
Surgically confirmed endometriosis was found in 62% of adolescents with pain, 75% with chronic pelvic pain resistant to treatment, and 70% with dysmenorrhea.

This data is compelling evidence that the earliest signs of endometriosis often present much earlier than adulthood. However, unless medical providers are educated about adolescent prevalence, diagnostic delays will persist.

Diagnostic Limitations

Another reason why adolescent endometriosis is underdiagnosed is due to a historical lack of Tier 1 (low cost, easy to use, highly accurate, and noninvasive) rapid diagnostic tests for endometriosis.

Prior to advancements in noninvasive technology, medical providers could only rely on laparoscopic surgery with histological confirmation to definitively diagnose endometriosis. Due to its invasive nature and high cost though, most medical providers understandably hesitated to perform this procedure on young patients.

Furthermore, laparoscopic surgery is not without its limitations. Endometrial lesions can be difficult to identify even for the most experienced surgeon, especially if they are obscured, hidden deep within the anatomy, or outside the pelvic cavity. [4, 5]

Alternative diagnostic methods, such as a gynecological examination and transvaginal ultrasound can help providers make a clinical diagnosis, but these Tier 2 methods are often not appropriate for adolescents who are not yet sexually active, posing an additional barrier to early detection in young patients. [2]

Marginalized, Ignored, and Silenced

Adolescence is a significant developmental period, often characterized in society by high hormone levels and intense emotions. This can sometimes create an environment where adolescents feel unheard, dismissed, or ignored due to stigmas associated with their age group. In turn, they can feel helpless to advocate for themselves about legitimate health concerns, especially regarding the irrefutable symptoms they are experiencing.

As one study noted:

“[A] social context that stigmatizes and dismisses menstrual health, inequitable gender norms, and a lack of endometriosis knowledge really affect adolescents' perception of symptoms and ability of asking for help.” [3]

Adolescents may feel they must suffer in silence. The unfortunate reality is that the longer the delay, the more time the disease has to advance, significantly diminishing their quality of life. That is why it is important to raise awareness about the prevalence of endometriosis in this age group.

Know the Warning Signs of Adolescent Endometriosis

One way to raise awareness about adolescent endometriosis is by learning to recognize its well-documented warning signs. We covered common endometriosis symptoms in depth in our blog post, Understanding Endometriosis: A Detailed Look at Common Symptoms .

Here is a quick summary:

Pelvic pain (with or without periods)
Painful periods (dysmenorrhea)
Pain during sexual intercourse (dyspareunia)
Heavy or irregular menstrual bleeding
Painful urination during periods (dysuria)
Painful bowel movements during periods (dyschezia)
Lower back, buttock, or thigh pain
Pain during ovulation
General abdominal pain, bloating, and bowel habit changes
Rectal bleeding
Excessive fatigue
Disruption of normal daily function and activities

Additionally, a recent study noted:

“Endometriosis may also debut with atypical symptoms such as genitourinary symptoms, nausea, dyschezia, painful bowel movements, constipation or diarrhea, pain during exercise, depression, anxiety, sleep disturbances during menses, migraines, or severe headache. These symptoms manifest earlier in life among adolescents with endometriosis and can debilitate, leading to school absenteeism, negatively affecting social relationships and significantly impairing their quality of life.” [2]

By knowing what to look for, parents can better advocate for adolescents and consult early with a medical professional.

One Teen's Journey to Relief after Endometriosis Diagnosis

Early detection of endometriosis can have a tremendous impact on the quality of life of young women. One 16-year-old in the United Kingdom shared with us how early detection restored her hope and quality of life. (We intentionally withheld her name to protect her privacy.)

The young woman had been suffering from increasing pain and heavy bleeding during, and sometimes between, her periods. Previous treatments were ineffective, causing her to miss school and activities because her pain was so severe. Because her mother had been diagnosed with endometriosis (suggesting a family history of this condition), they sought out an endometriosis specialist, who recommended the ENDOSURE TEST .

Here’s what the young woman had to say:

“The gynecologist gave me some options, including laparoscopic surgery, but he didn’t advise it because I’m only 16-years-old. He also gave me the option of taking the 30-minute, painless ENDOSURE TEST. Because it was noninvasive, my mom and I were eager to try it, and I’m so glad I did. The test confirmed I have endometriosis.

I’m grateful that I found out early because it means that now I am in control of my life. I was prescribed a new pill called Ryeqo, which has been life changing. Now, I only have moderate pain when I ovulate – nothing like it used to be."

"I can play sports again, and I’m not missing school because of terrible pain and heavy periods.”

Thanks to a positive ENDOSURE TEST result, this young woman’s doctor was able to prescribe a targeted treatment to which she positively responded, ending a long uncertain journey of ineffective treatments.

A New Era of Diagnostic Testing

Noninvasive testing such as the ENDOSURE TEST overcomes many of the limitations of traditional diagnostic approaches, like laparoscopic surgery. As the only truly Tier 1 diagnostic test, it empowers medical providers to detect the presence of endometriosis in patients of any age, at any disease stage, in any anatomical location without the need for surgery, and at a fraction of the cost.

This noninvasive tool enables adolescents to access timely and accurate diagnosis, effectively breaking the cycle of symptom normalization and dismissal. It provides a pathway for them to access the personalized treatments they deserve.

How to Advocate for Timely Diagnosis

Because adolescent endometriosis is still largely underrecognized, it is important to know how to advocate for timely diagnosis.

For parents: trust your instincts. If your teenager is experiencing severe period pain, consult with a medical provider. Don't accept the inappropriate “normal period pain” answer if symptoms are debilitating; debilitating pain is not a normal part of growing up. Educate yourself and insist upon a Tier 1 test like the ENDOSURE TEST. Seek out a second opinion if you must, ideally from an endometriosis specialist.

For teens: it's not “in your head” and you are not being dramatic. It's never normal to have severe period pain. Don't be afraid to speak up and talk openly with your parents or a trusted adult about the pain you are experiencing.

Conclusion

Adolescent endometriosis is highly prevalent. Increased awareness about its prevalence can empower both parents and adolescents to advocate for a timely diagnosis and early intervention.

Furthermore, advancements in technology – and now with the availability of a Tier 1 test to detect endometriosis noninvasively – have overcome traditional barriers to diagnosis and collaborative, targeted treatment so that no adolescent woman must continue suffering for years without knowing what is wrong.

If you suspect your teenager has endometriosis, contact your medical provider and request the ENDOSURE TEST . They do not have to continue suffering.

References:

Shim JY, Laufer MR, King CR, Lee TTM, Einarsson JI, Tyson N. Evaluation and Management of Endometriosis in the Adolescent. Obstet Gynecol. 2024 Jan 1;143(1):44-51. DOI: 10.1097/AOG.0000000000005448. Accessed June 9, 2025. https://pubmed.ncbi.nlm.nih.gov/37944153/ .
Viscardi MF, Piacenti I, Musella A, Cacciamani L, Piccioni MG, Manganaro L, Muzii L, Porpora MG. Endometriosis in Adolescents: A Closer Look at the Pain Characteristics and Atypical Symptoms: A Prospective Cohort Study. J Clin Med. 2025 Feb 19;14(4):1392. DOI: 10.3390/jcm14041392. PMID: 40004922; PMCID: PMC11856142. Accessed June 9, 2025. ttps://pubmed.ncbi.nlm.nih.gov/40004922/ .
Lazzeri L, et al. How to Manage Endometriosis in Adolescence: The Endometriosis Treatment Italian Club Approach. Journal of Minimally Invasive Gynecology. 2023;30(8):616-626. Accessed June 9, 2025. https://www.jmig.org/article/S1553-4650(23)00117-6/fulltext .
Pascoal E, Wessels JM, Aas-Eng MK, et al. Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research. Ultrasound Obstet Gynecol. 2022;60(3):309-327. DOI:10.1002/uog.24892. Accessed June 9, 2025. https://pubmed.ncbi.nlm.nih.gov/35229963/ .
Simko S, Wright KN. The future of diagnostic laparoscopy - Cons . Reprod Fertil. 2022;3(2): R91-R95. Published 2022 Apr 20. DOI:10.1530/RAF-22-0007. Accessed June 9, 2025. https://pubmed.ncbi.nlm.nih.gov/35706581/ .

Diagnostic Testing for Endometriosis: Finally, a Tier-1 Diagnostic Test

mark@endosure.com (Mark Noar) — Wed, 21 May 2025 13:00:10 GMT

The ENDOSURE TEST is the first and only Tier-1 diagnostic test for endometriosis.

Until now, diagnosis of endometriosis has been limited by the absence of a highly accurate Tier-1 diagnostic test. With millions of women going undiagnosed with this debilitating disease for close to a decade, it is exacerbated by the fact that nonspecific and non-targeted treatment is also limited, which often results in less than satisfactory outcomes.

To a significant degree, this also limits medical providers, who subsequently face ongoing challenges in differentiating endometriosis symptoms from symptoms of conditions with similar presentations, causing diagnostic and treatment delays.

However, with the introduction of the first and only Tier-1 diagnostic test for this disease, the world is on the verge of a quantum shift in the diagnosis and treatment for endometriosis.

What Is a Tier-1 Diagnostic Test?

A Tier-1 diagnostic test typically refers to a highly accurate, fundamental assessment, or procedure that enables clinicians to effectively screen, monitor, or identify the specific underlying cause of a patient’s symptoms. Tier-1 diagnostic tests help providers move closer to an appropriate treatment specifically targeted to address the underlying cause of symptoms.

Three Tiers of Diagnostic Tests

There are three tiers of diagnostic tests, with each tier varying in purpose, speed, precision, and cost.

Tier-1 Diagnostic Tests

Tier-1 diagnostic tests are typically the first investigational tests medical providers use to detect the presence of disease. Tests in this category are highly accurate, easy to use, widely available, broadly applicable to the population without limitation, and provide rapid results. They are generally non-invasive or minimally invasive as well as low cost.

Anemia is one example of a condition where a physician may use a Tier-1 test, such as a complete blood count (CBC), to determine the underlying cause of a patient’s symptoms. A CBC measures a patient’s red blood cell count, hematocrit, and hemoglobin levels. If these markers are low, it may be enough for a physician to diagnose that the patient is anemic.

Tier-2 Diagnostic Tests

Tier-2 diagnostic tests are generally used as localizing tests. They are used to pinpoint where in the body the issue is occurring. Typically, Tier-2 tests are used either after a Tier-1 test is positive or warrants further exploration.

Tests in this category are generally more complex and take more time to receive results, and cost more than Tier-1 tests. They can be highly effective when appropriately used. For example, to better diagnose anemia, a Tier-2 test such as a stool blood test helps the physician determine if there is a problem with blood loss from a particular place in the body.

Tier-3 Diagnostic Tests

Tier-3 diagnostic tests are also localizing tests. The advantage of this category of tests is that a physician can visualize as well as treat the source of the problem. Tier-3 tests are much more complex, expensive, with results slower than other categories of tests. They generally offer the ability to combine treatment with diagnosis.

An example of a Tier-3 test in anemia is colonoscopy for identification of a bleeding colonic lesion like a polyp, with subsequent removal (polypectomy).

This multi-tiered approach to diagnostic testing is the standard for most diseases. Medical providers generally begin with Tier-1 tests - the fastest, most accessible tests - to determine whether a patient has a disease, and progress to more specialized, complex tests to localize and treat as needed.

However, for endometriosis, diagnostic laparoscopic surgery – a Tier-3 test with associated lower levels of accuracy, risks, and higher expense - has remained the diagnostic standard for a definitive diagnosis. This has changed.

A Call for a New Diagnostic Framework for Endometriosis

Prior to 2022, a Tier-1 diagnostic test did not exist to screen for endometriosis. This restricted medical providers to rely on Tier-2 imaging tests and diagnostic surgery (Tier-3) to localize endometrial lesions and begin therapy. A significant limitation of this approach has been that neither imaging studies nor laparoscopic surgery is suitable for diagnosing all subtypes of endometriosis. [1, 2, 3]

Tier-2 Imaging Tests Limitations

Transvaginal ultrasound (TVUS) and MRI are the two most common imaging tests used to clinically diagnose endometriosis. Though both are useful in detecting deep infiltrating endometriosis, they fall short in reliably detecting superficial endometriosis. [2]

Tier-3 Diagnostic Laparoscopic Surgery Limitations

Diagnostic laparoscopic surgery allows medical providers to visually confirm endometrial lesions and obtain histopathologic confirmation on biopsied tissue. Generally, histopathologic confirmation is considered definitively accurate. The limitation of laparoscopic surgery lies in the surgeon’s ability to identify the lesions. A surgeon may not be able to see and consequently remove suspicious lesions if they are hidden deep within or outside the pelvic cavity, which may result in a false negative for disease. [2, 3]

Moreover, Tier-3 diagnostic laparoscopic surgery is invasive, expensive, and has associated risks. The number of women who are offered or opt to undergo this procedure is comparably small compared to the number of women who continue to suffer from the symptoms of endometriosis without a formal diagnosis. This disparity contributes to diagnostic delays and disease progression.

Why a Tier-1 Diagnostic Test for Endometriosis Is Critically Important

The need for a Tier-1 diagnostic test in endometriosis cannot be overstated. Without an objective method to reliably detect the irrefutable presence of this complex disease, medical providers may be confined to work in the dark and suggest limited empiric non-targeted therapy.

Furthermore, without access to tests that offer rapid results, women will continue suffering an average of 8.6 years [4] or more with chronic, often-debilitating symptoms and ineffective treatments before ever knowing what is wrong. Timely diagnosis and effective treatment of endometriosis are vital to a patient’s quality of life.

As Dr. Larry Glazerman, a leading gynecologist, explains:

“The ability to diagnose endometriosis without an invasive surgical procedure and avoid the typical 7- to 10-year delay in diagnosis can revolutionize the management of this debilitating condition for millions of women around the world.”

With a reliable Tier-1 diagnostic test for endometriosis in place, medical providers can confidently screen and diagnose greater numbers of patients, facilitating warranted, faster and more targeted therapy intervention.

The ENDOSURE TEST: A Tier-1 Diagnostic Test for Endometriosis

As the very first Tier-1 diagnostic test for endometriosis, the ENDOSURE TEST is positioned to shift the entire paradigm in how medical providers detect and treat endometriosis. It is:

Low cost
Easy-to-use
Noninvasive
Rapid result (30 minutes)
Highly accurate
No population-related use restriction
Surgically verified

It fills all the major requirements of a Tier-1 diagnostic test and directly addresses a significant gap in endometriosis diagnostics.

More importantly, the ENDOSURE TEST equips medical providers with the means to overcome many of the limitations associated with using imaging studies and laparoscopic surgery alone to detect endometriosis. As a non-invasive, highly accurate, 30-minute test, capable of reliably detecting endometriosis at any age and anywhere in the anatomy, the ENDOSURE TEST enhances the utility of Tier-2 and Tier-3 tests because physicians will know that the disease is already present.

The TEST also empowers medical providers to better manage the disease by giving them insight into which patients will likely respond to treatment. Dr. David Griffiths, a leading gynecologist in the United Kingdom, explains:

“The ENDOSURE TEST has proved an invaluable tool for my practice. It has been particularly beneficial for my adolescent patients. I can now offer a reliable and noninvasive test to confirm my clinical suspicions of endometriosis/adenomyosis without the need for surgery.”

Conclusion

Diagnostic delays in endometriosis have largely been due to the lack of Tier-1 diagnostic tests - low cost, highly accurate, and easily accessible tests that can quickly and reliably detect the presence of endometriosis.

Since the introduction of the ENDOSURE TEST in 2022, this is no longer the case. Medical providers are now empowered to detect endometriosis at its earliest stages and offer targeted, personalized therapy to their patients. Patients, too, are empowered because they no longer must wait nearly a decade before ever knowing what is wrong, offering hope to every woman afflicted with this horrible disease.

If you think you have endometriosis, talk to your healthcare provider.

Learn more about the ENDOSURE TEST .

References:

1. Mettler L, Schollmeyer T, Lehmann-Willenbrock E, et al. Accuracy of laparoscopic diagnosis of endometriosis. JSLS. 2003;7(1):15-18.

2. Pascoal E, Wessels JM, Aas-Eng MK, et al. Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research. Ultrasound Obstet Gynecol. 2022;60(3):309-327. doi:10.1002/uog.24892

3. Simko S, Wright KN. The future of diagnostic laparoscopy - Cons. Reprod Fertil. 2022;3(2):R91-R95. Published 2022 Apr 20. doi:10.1530/RAF-22-0007

4. Frankel LR. A 10-Year Journey to Diagnosis With Endometriosis: An Autobiographical Case Report. Cureus. 2022 Jan 17;14(1):e21329. doi: 10.7759/cureus.21329. PMID: 35186587; PMCID: PMC8849430.

EndoSure Announces a New Strategic Alliance with Maipl Therapeutics, Inc.

info@bostonwebpartners.com (Jonathan Eilberg) — Tue, 20 May 2025 15:26:32 GMT

MAIPL THERAPEUTICS, INC. FORMS STRATEGIC ALLIANCE WITH ENDOSURE, INC. TO FACILITATE FIRST‑IN‑HUMAN TRIAL OF NOVEL NON‑HORMONAL ENDOMETRIOSIS THERAPY

SCARSDALE, N.Y., May 20, 2025 /PRNewswire/ --  Maipl Therapeutics, Inc. ("Maipl"), a biopharmaceutical company focused on first‑in‑class, non‑hormonal therapies for women's health, today announced a strategic alliance with Endosure, Inc., the developer of the ENDOSURE TEST—the only Tier-1 non‑invasive, 30-minute and highly accurate diagnostic with rapid results capable of diagnosing or excluding the presence of endometriosis in any anatomical location. The collaboration will leverage the ENDOSURE TEST to expedite Maipl's clinical studies of MA-4604, a potent and selective antagonist of the Prostaglandin‑F2α receptor (FP), with the goals of accelerating patient identification, enrollment and pharmacodynamic assessment.

Click to Read the Full Press Release >>

Understanding Endometriosis: A Detailed Look at Common Symptoms

info@bostonwebpartners.com (Jonathan Eilberg) — Fri, 09 May 2025 22:26:27 GMT

Endometriosis is a chronic condition where tissue similar to the lining of the uterus grows outside of the uterus, often causing significant discomfort and complications. Affecting millions of women worldwide, it can profoundly impact quality of life. Recognizing its symptoms is crucial for early diagnosis and management. Below, we explore the common symptoms of endometriosis in detail, shedding light on their characteristics and effects.

1. Pelvic Pain (With or Without Periods)

Pelvic pain is a hallmark of endometriosis, often described as a deep, aching, or cramping sensation in the lower abdomen or pelvis. This pain may occur independently or intensify during menstrual periods. Unlike typical menstrual cramps, endometriosis-related pelvic pain is relentless and can persist throughout the month, varying in intensity. It may feel like a constant dull ache or sharp, stabbing pain, and can radiate to the lower back or thighs. The severity often correlates with the metabolic activity of endometrial tissue growth rather than the stage, extent, or location of the disease.

2. Painful Periods (Dysmenorrhea)

Dysmenorrhea, or intensely painful periods, is one of the most common symptoms of endometriosis. Women may experience severe cramping that begins before menstruation and continues for several days. The pain can be debilitating, interfering with daily activities and sometimes requiring strong pain relief. This is caused by the inflammation and irritation from endometrial tissue outside the uterus, which responds to hormonal changes during the menstrual cycle, leading to localized bleeding and pain.

3. Pain During Sexual Intercourse (Dyspareunia)

Dyspareunia refers to pain during or after sexual activity, often described as a deep, internal discomfort in the pelvic region, it may also present as a superficial form at the initiation of penetration. . This symptom arises when endometrial implants or scar tissue (adhesions) in the pelvic cavity are disturbed during intercourse. The pain may vary depending on the position or depth of penetration and can persist for hours afterward, affecting emotional well-being and intimate relationships.

4. Infertility

Infertility is a significant concern for many women with endometriosis, with up to 30-50% of affected women experiencing difficulty conceiving. Endometriosis can impair fertility by causing adhesions that distort pelvic anatomy, blocking fallopian tubes, or affecting egg quality and implantation. Inflammation from endometrial tissue may also create a hostile environment for sperm or embryos. Women with endometriosis may require fertility treatments, such as in vitro fertilization (IVF), to conceive.

5. Heavy or Irregular Menstrual Bleeding

Women with endometriosis may experience abnormally heavy menstrual flow (menorrhagia) or irregular bleeding, such as spotting between periods. Heavy bleeding can lead to prolonged periods, passing large clots, or the need to change sanitary products frequently. This symptom is thought to result from hormonal imbalances or the presence of endometrial tissue affecting the uterine lining’s normal shedding process. This may occur with a different form of endometriosis known as adenomyosis, which is when the endometriosis tissue invades the wall of the uterus.

6. Painful Urination During Periods (Dysuria)

Dysuria, or painful urination during menstruation, occurs when endometrial tissue grows near the bladder or urethra. This can cause a burning or stinging sensation during urination, sometimes accompanied by an urgent need to urinate or frequent trips to the bathroom. The pain is typically cyclical, worsening during periods due to inflammation and hormonal changes affecting the pelvic tissues.

7. Painful Bowel Movements During Periods (Dyschezia)

Dyschezia refers to painful or difficult bowel movements, particularly during menstruation. When endometrial implants affect the rectum, intestines, or surrounding pelvic structures, women may experience cramping, straining, or sharp pain during defecation. This symptom can be accompanied by constipation, diarrhea, or a feeling of incomplete bowel emptying, especially during periods.

8. Lower Back, Buttock, or Thigh Pain

Pain radiating to the lower back, buttocks, or thighs is common in endometriosis, often due to referred pain from pelvic inflammation or nerve irritation, it may also be associated with endometriosis lesion in the sacrum or spinal nerves. This pain may feel like a deep ache or sharp twinges and can worsen during periods or physical activity. It may also be mistaken for sciatica or musculoskeletal issues, complicating diagnosis.

9. Pain During Ovulation

Some women with endometriosis experience sharp or cramping pain during ovulation, known as mittelschmerz. This mid-cycle pain occurs when endometrial tissue stimulated by estrogen secretion, irritates the ovaries or surrounding structures during the enlargement of the egg follicles or release of an egg. The discomfort may last a few hours to a couple of days and can be accompanied by bloating or nausea.

10. General Abdominal Pain, Bloating, and Bowel Habit Changes

Generalized abdominal pain, bloating (often called “endo belly”), and changes in bowel habits—such as diarrhea, constipation, or alternating patterns—are frequent in endometriosis. These symptoms often worsen during menstruation due to inflammation and hormonal fluctuations. Bloating may cause visible abdominal distension, discomfort, or a feeling of fullness, impacting daily comfort and body image.

11. Excessive Fatigue

Chronic fatigue is a less recognized but debilitating symptom of endometriosis. Women often report feeling exhausted, even after adequate rest, due to the physical toll of chronic pain, inflammation, and hormonal imbalances. Fatigue can also stem from disrupted sleep caused by pain or heavy bleeding, contributing to a cycle of reduced energy and emotional strain.

12. Rectal Bleeding

Rectal bleeding during menstruation, though rare, can occur when endometrial tissue invades the rectal or intestinal wall. This may manifest as blood in the stool or bright red bleeding during periods, often accompanied by painful bowel movements. This symptom requires prompt medical evaluation to rule out other gastrointestinal conditions.

Conclusion

Endometriosis presents a complex array of symptoms that can vary widely in intensity and impact. It has been variably characterized as an inflammatory, auto immune or motility disorder. From debilitating pelvic pain and painful periods to infertility and gastrointestinal issues, these symptoms can significantly affect physical, emotional, and social well-being.

Up until recently, it has been difficult to diagnose endometriosis due to the absence of a Tier 1 diagnostic test. These First-Tier diagnostic tests are now available and known as the ENDOSURE TEST . First Tier diagnostic tests are important because they provide the earliest indication of the presence of disease with a highest accuracy and are usually the simplest to perform. Without Tier-1 testing, diagnosis is difficult and relies on less accurate anatomic localization testing like transvaginal ultrasound, MRI and invasive laparoscopic surgery. This has resulted in treatment to be empirical rather than targeted, only prolonging the time to actual diagnosis while the disease progresses.

If you or someone you know experiences these symptoms, consult a healthcare provider for a thorough evaluation and insist on the Tier-1 ENDOSURE TEST. Early diagnosis and tailored treatment—ranging from pain management to surgical intervention—can help manage symptoms and improve quality of life. Awareness and education are key to empowering women to seek the care they need.

How Pelvic Physiotherapy Helps Relieve Endo Pain

lhird@endosure.com (Leah Hird) — Wed, 30 Apr 2025 15:35:55 GMT

Physical therapy is a powerful treatment option for some patients who may be considering surgery for relief from endometriosis symptoms.

Debilitating pain is often a major symptom of endometriosis, interfering with a woman’s daily activities and overall quality of life. Traditional treatments range from lifestyle and diet modifications to medications and even surgery.

However, those are not the only options. Pelvic physiotherapy, or pelvic physical therapy, is an option that can be powerfully effective in providing relief for those suffering from endometriosis pain.

In a recent podcast interview, Dr. Amanda Olsen, a leading pelvic physiotherapist, and award winner of the 2025 Elizabeth Novel Award from the Academy of Pelvic Health and Physical Therapy, shared her insights with ENDOSURE, INC.’s Mark Noar and EndoDiagnosis, Inc.’s Carolyn Plican on how pelvic physiotherapy can help patients manage endometriosis symptoms.

What Is Pelvic Physiotherapy?

For nearly 45 years, pelvic physiotherapy has offered patients struggling with pelvic floor dysfunction specialized, targeted therapy to regain control of their pelvic floor. It is an area of medicine that continues to grow, with widespread availability in many parts of the world, including the United States, Canada, Australia, the United Kingdom, and South Africa.

How to Access a Pelvic Physiotherapist

There are a number of ways to access a pelvic physiotherapist. Patients can go through their primary care provider, gynecologist, gastroenterologist, or pain specialist, depending on country of residence. In many states within the United States, patients can schedule an appointment directly with a physiotherapist without needing to obtain a referral from their primary care physician.

In recent years, physiotherapy has grown in popularity, as more patients advocate for themselves. Dr. Olsen reflects, “I’ve been doing pelvic health for 15 years now, and when I started 15 years ago, it was a big undertaking to inform not just the patient population, but also providers as to what our skillset is and what we have to offer. Now the popularity is growing a lot. There’s been a lot more patient advocacy on behalf of themselves. They are requesting it from their providers, and they are seeking us out individually.”

No matter how a patient may access a physiotherapist, the therapist will coordinate with the patient’s doctor and care team about the plan of care to ensure a comprehensive approach to care.

Pelvic Physiotherapy for Patients with Endometriosis

Physiotherapists assess patients with pelvic pain differently from those diagnosed with endometriosis. Having an endometriosis diagnosis first will influence their treatment approach.

When patients present with pelvic pain, a physiotherapist will generally complete a thorough evaluation, paying special attention not only to the pelvic floor but also to how the patient’s spine and hips move as well as the strengths and weaknesses of relevant muscles.

On the other hand, when patients present with pelvic pain associated with endometriosis, the physiotherapist will take a more holistic assessment because they already know they are managing much more than a musculoskeletal condition. They are managing a complex, systemic disease that affects the entire body.

The therapist will assess the patient’s daily activities, exercise levels, and nutrition intake. They will also look for certain patterns unique to those with endometriosis, such as:

Guarding tendencies in the pelvic floor (tight, rigid muscles)
Weak muscle coordination
Muscles that are painful and tender when palpated (possibly indicating endometriomas in the muscles or fascia)

Benefits of Pelvic Physiotherapy for Patients with Dyspareunia

For patients with dyspareunia, or painful intercourse, due to endometriosis, pelvic physiotherapy may provide relief. Dyspareunia is often the result of subconscious contractions of the pelvic floor muscles when penetration is about to occur, making it impossible or challenging and painful. It can also be caused by the presence of tight points in the muscles deep in the pelvic floor.

Pelvic physiotherapy addresses these issues by using gentle manual techniques or special tools, like a pelvic wand or dilators, to improve mind-body coordination so that the vaginal muscles relax and better positioned. Physiotherapy also enables the muscles themselves to be more flexible and mobile to facilitate easier penetration.

Benefits of Pelvic Physiotherapy for Patients with Adhesions

For patients with adhesions, there are some manual techniques a physiotherapist can employ to increase blood flow. Therapists trained in visceral mobilization manually enter the pelvic floor or abdomen to encourage pelvic muscles to relax. In cases of severe endometriosis and complex adhesions, however, therapists should defer to surgeons.

For Patients without an Endometriosis Diagnosis: The ENDOSURE TEST Fills the Gap

Though a diagnosis is helpful, if a patient has not been formally diagnosed with endometriosis, it does not mean a physiotherapist cannot help. In fact, a physiotherapist may actually be able to raise suspicion of endometriosis.

“It’s really helpful to have that diagnosis in place ahead of time,” Dr. Olsen explains, “but if they don’t have it when we are examining, our suspicion level rises when the muscles are not responding in a very linear pattern like we’d expect them to.”

Fortunately, with the ENDOSURE TEST , it is possible for patients to have an accurate diagnosis before they see a physiotherapist. The easy-to-use, non-invasive, highly accurate, 30-minute TEST enables healthcare providers to quickly resolve whether endometriosis is the source of the patient’s pain.

With an accurate diagnosis to guide pelvic therapy, physiotherapists are empowered to offer the targeted, personalized therapy patients need to find relief from their endometriosis symptoms.

Pelvic Physiotherapy as a Treatment Alternative to Surgery for Select Patients

When it comes to treatments for pain and other symptoms commonly associated with endometriosis, medication, diet, and surgery are well-known options. However, pelvic physiotherapy can also offer some patients significant relief – sooner than surgery and for far less cost.

In Dr. Olsen’s estimation, ten percent of all endometriosis patients may be able to avoid surgery by seeing a pelvic physiotherapist. For that reason, she strongly recommends patients consult with one before considering surgery.

“A lot of times when someone is staring down the barrel of surgery, they have to look at their whole life, like when am I going to be able to schedule this, or what’s the cost going to be. That’s a problem here in the United States,” says Dr. Olsen.

“A lot of providers are cash only or it is a high deductible on their insurance plan, so they’re having to schedule it out. It’s not going to be next week, [which means] they’re not going to get relief next week. It might be months out,” she explains. “We’re going to help them taper that pain down today. It’s not going to be a magic wand, and it’s not going to be easy, but we are there to help them start making changes right away.”

Daily Function Value

Pelvic physiotherapy is also helpful for daily function. A therapy program can educate and empower patients with the tools they need to make life easier at home. Daily functions such as having bowel movements, for instance, can be especially challenging for those with endometriosis.

Physiotherapy instructs patients on appropriate body positioning to facilitate movement. Specific programs can also provide personalized exercise recommendations to maintain patients’ mobility.

Post Surgical Value

Pelvic physiotherapy aids in restoring function and mobility after surgery. A physiotherapist can also assess whether scars are healing appropriately and address muscle restrictions that may develop around the scars early with manual techniques to maintain mobility.

Additionally, a therapist can evaluate the patient’s pelvic floor to ensure normal muscle contractions and relaxations. Early intervention may be able to prevent neuromuscular patterns that can interfere with normal bowel, bladder, and sexual functions. Dr. Olsen recommends patients follow up with a physiotherapist six weeks after surgery.

What Newly Diagnosed Endometriosis Patients Should Know

How Soon Should Patients Seek Pelvic Physiotherapy?

Dr. Olsen recommends patients see a physiotherapist immediately after being diagnosed. In many cases, patients have been experiencing endometriosis symptoms for years before diagnosis. Immediate intervention will allow some patients to begin experiencing relief and improve daily function.

Is There an Age Limit for Pelvic Physiotherapy?

No. Pelvic physiotherapists work with endometriosis patients of all ages. They will modify treatment depending on the age of the patient though. For example, Dr. Olsen explains adolescent patients will not receive an internal evaluation without first being evaluated by their gynecologist, obtaining parental consent, and consenting to it themselves.

What to Expect at the First Appointment

The first appointment with a pelvic physiotherapist will focus on understanding the patient’s medical history, defining goals for therapy, completing a physical assessment to identify areas to improve, and even validating their experience.

Example Questions Regarding Medical History

How well is your bladder functioning?
How many times a day do you urinate?
Do you ever leak urine?
How well is your bowel moving?
What does your stool look like? Is it difficult? Is it painful?
Are you sexually active? Do you experience pain? Is the pain when you first start or is it when it’s deeper in?

Goals for Therapy

These goals are established by the patient. Whether those goals are to work a full day without pain or to improve fertility for those wishing to conceive, the physiotherapist will structure their treatment plan to help the patient reach those goals.

Physical Assessment

During a physical assessment, the therapist will observe how the patient moves, including bending over and hip movement. The therapist will measure strength and gently press into the abdomen to see how well musculoskeletal structures are moving.

Then, the therapist will complete a vaginal assessment. Unlike a typical visit with the gynecologist, this assessment does not involve a speculum. Instead, the therapist will use one finger to evaluate control of the pelvic floor and assess how well the mind and body coordinate to contract and relax those muscles.

Last, the therapist will touch for areas of pain and document those areas for proper analysis. Once the full assessment is complete, the physiotherapist will develop a plan of care to begin therapy.

Validation

Unfortunately, the journey for many patients with endometriosis is often marked by supposedly “normal” imaging studies and improper dismissal despite their pain. Physiotherapy can provide patients with the validation they have been missing. Dr. Olsen shares:

“What I’ve found in 15 years of practice is, a lot of times too, we’re the first person who’s heard them out and told them that they’re not crazy…. [Doctors have told them it] sounds like your periods are rough. You know, this is just how it goes for you. They are extremely traumatized by that because they feel like they’re crazy. So, we do spend a lot of time listening and reassuring and validating their experiences.”

Conclusion

Surgery is not the only treatment option available for those needing relief from the chronic, often debilitating symptoms of endometriosis. Pelvic physiotherapy is a non-invasive alternative that can offer some patients relief and greater control over their daily lives.

If you have questions about whether pelvic physiotherapy is right for you, consult with your doctor.

You can listen to Dr. Olsen's full interview here , or wherever you listen to your favorite podcasts.

Learn more about the ENDOSURE TEST.

Endometriosis: A New Era in Diagnostics

Wed, 16 Apr 2025 00:53:10 GMT

Laparoscopic surgery is no longer the only way to diagnose endometriosis. There is now a new breakthrough endo test on the horizon.

I s it possible to diagnose endometriosis without surgery? Many trustworthy websites show that although a clinical non-surgical diagnosis may be possible, laparoscopic surgery with histopathological confirmation is the only definitive way to diagnose endometriosis. However, this is no longer true; advancements in technology have made it possible to definitively diagnose endometriosis without invasive surgery.

Why a Non-Surgical Diagnostic Method Is Necessary

Laparoscopic surgery has long been held as the gold standard for endometriosis diagnosis, but it is not without its limitations.

Compared to other methods physicians may use to diagnose endometriosis , the laparoscopic approach requires surgeons to first visually confirm the presence of endometrial lesions, then remove a sample, send it to the pathology lab, and wait for histopathologic confirmation.

One limitation of this approach though is that the lesions can be difficult to identify if they are obscured or do not have the characteristic appearance of an endometrial lesion. 1 Another limitation is that this approach relies heavily on a surgeon’s experience in identifying the lesions. One study found 25% of the lesions surgeons marked as “atypical-appearing tissue not presumed to be endometriosis” were histologically confirmed as endometriosis. 2 Even with extensive experience, a surgeon may not see the lesions if they are hidden deep within different organs or outside the pelvic cavity. For these reasons, studies suggest laparoscopic diagnosis has limited accuracy. 2, 3 Generally, histological confirmation is definitively accurate.

Without a definitive diagnosis, patients and healthcare providers face significant challenges in determining when to treat or choosing an effective course of treatment. Timely diagnosis and treatment of endometriosis are critical to a patient's quality of life. Diagnostic delays mean women continue suffering the chronic and often-debilitating pain associated with endometriosis for years before ever knowing what is wrong.

A faster way to reliably diagnose endometriosis means patients can be treated at much earlier stages of their disease.

The Future of Endometriosis Care

ENDOSURE, INC. envisions a future in endometriosis care where timely diagnosis is no longer a barrier to effective disease management. Even more so, we see a future where no woman must wait nearly a decade – the current global average – before receiving a definitive diagnosis.

The ENDOSURE TEST has already begun ushering in this new era of endometriosis diagnostics. Surgically verified studies demonstrated 99% accuracy, with the TEST capable of detecting endometriosis in patients of any age, at any stage, anywhere in the body - offering patients a remarkably accurate and timely diagnosis.

The endo test is actively being used in many gynecology practices around the world. It has made it possible for healthcare providers not only to reliably diagnose endometriosis earlier than ever before but also to begin targeted treatment without delay. This has had an enormous positive effect on the lives and livelihoods of so many to date.

Conclusion

A new era of endometriosis diagnostics is here. Laparoscopic diagnosis is no longer the only definitive way to diagnose endometriosis. The ENDOSURE TEST is now a complementary verifiable option, effectively overcoming the limitations of laparoscopic diagnosis and other imaging options. If you think you have endometriosis, talk to your healthcare provider. Learn more about the ENDOSURE TEST.

References:

1. Mettler L, Schollmeyer T, Lehmann-Willenbrock E, et al. Accuracy of laparoscopic diagnosis of endometriosis. JSLS. 2003;7(1):15-18.

3. Simko S, Wright KN. The future of diagnostic laparoscopy - Cons. Reprod Fertil. 2022;3(2):R91-R95. Published 2022 Apr 20. doi:10.1530/RAF-22-0007

How has Endometriosis Typically Been Diagnosed?

info@bostonwebpartners.com (Jonathan Eilberg) — Thu, 20 Mar 2025 13:17:02 GMT

Endometriosis is typically diagnosed through a combination of medical history, physical examination, imaging, and sometimes surgical procedures. Below is a a step-by-step breakdown of how diagnosis usually occurs.

1. Medical History and Symptoms Discussion:

A healthcare provider will start by taking a detailed medical history, discussing symptoms like:
Pelvic pain, particularly severe menstrual cramps.
Pain during or after sex.
Chronic lower back or abdominal pain.
Painful bowel movements or urination during menstrual periods.
Infertility issues.
Heavy or irregular menstrual bleeding.
Change in bowel habits, nausea, bloating

2. Physical Examination:

A pelvic exam might be performed to feel for abnormalities like cysts or scars behind the uterus. However, endometriosis can be deep-seated and not always palpable during a routine exam.

3. Imaging Tests:

Ultrasound: A transvaginal ultrasound can sometimes detect ovarian endometriomas (chocolate cysts) or large areas of endometriosis. However, it's not effective for diagnosing mild endometriosis which makes up 85% of disease.
MRI: Magnetic Resonance Imaging can be more detailed than ultrasound, particularly useful for identifying deep infiltrating endometriosis or endometriomas, but it's not conclusive for early forms of the disease.

4. Laparoscopy:

This is considered the current standard of care for definitive diagnosis:
Procedure: Laparoscopy involves making small incisions in the abdomen through which a laparoscope (a thin tube with a camera) is inserted to view the pelvic organs.
Visual Confirmation: The surgeon looks for endometrial tissue outside the uterus, which can appear as dark spots, powder burns, or red implants. However, endometriosis can be anatomically hidden and not always visible.
Biopsy: After the surgeon visually localizes the disease, biopsies of suspicious tissue is surgically removed during laparoscopy and sent to pathology lab for histological confirmation, although, depending on degree of disease infiltration, visual inspection is can be sufficient for diagnosis.

5. Less Common Methods:

CA-125 Blood Test: Sometimes used, but not specific or sensitive enough for diagnosing endometriosis alone, as levels can be elevated in other conditions too.

6. Diagnostic Challenges:

85% of Endometriosis can be very subtle and not visible on imaging or even during laparoscopic surgery if the disease is minimal or very deep and hidden within tissues.
Symptoms can mimic other conditions like IBS, PID, or even appendicitis, leading to diagnostic delays.
Disease can be difficult to localize, particularly if situated outside the pelvic cavity.

The diagnosis of endometriosis often involves ruling out other causes of similar symptoms. Due to the invasive nature of laparoscopy, it might be reserved for cases where conservative treatments fail or when there's a high suspicion of endometriosis, especially in cases dealing with infertility. If you suspect you might have endometriosis, consulting with a gynecologist or a specialist in endometriosis should be the next step.

Good News on the Horizon

EndoSure, through its groundbreaking platform from ENDOSURE, INC., promises to usher in a new era of hope and empowerment for the endometriosis community. With its revolutionary ENDOSURE TEST —the only non-invasive, 30-minute diagnostic tool offering exceptional accuracy—this transformative innovation aims to improve the lives of millions of women worldwide. For far too long, the journey to an endometriosis diagnosis has been marred by delays, averaging 8.6 years, invasive procedures like laparoscopy, and dismissed symptoms, leaving countless individuals to suffer in silence. The ENDOSURE TEST seeks to dismantle these barriers by providing a rapid, painless, and highly reliable alternative that detects endometriosis at all stages, anywhere in the anatomy in patients of any age using cutting-edge electroviscerography (EVG) technology to identify a unique biomarker or myoelectrical "fingerprint" idiosyncratically associated with the presence of the disease.

The hope EndoSure brings is multifaceted: it offers the promise of early detection, enabling timely and targeted treatment to minimize disease progression and alleviate debilitating symptoms like chronic pelvic pain and infertility. By empowering physicians with objective data in mere minutes , it shifts the diagnostic paradigm from uncertainty to clarity, sparing women the physical and emotional toll of prolonged uncertainty or unnecessary surgeries.

Beyond individual relief, EndoSure’s commitment to raising awareness and expanding global access—evidenced by partnerships with distributors across the UK, Nordic countries, and beyond—ignites a collective hope for systemic change. This is a beacon for a future where endometriosis is no longer a silent epidemic, but recognized as a serious disease met with swift, compassionate, and effective treatment options, restoring quality of life and dignity to those affected. Post treatment, the ENDOSURE TEST can also be used to monitor treatment efficacy as well as to discover if the disease has returned.

Bringing Hope During Endometriosis Awareness Month

mark2112rogers@yahoo.com (Mark Rogers) — Mon, 03 Mar 2025 10:33:46 GMT

Early Diagnosis leads to better Patient Outcomes | Endosure

As we enter the third day of Endometriosis Awareness Month, it's crucial that we keep the spotlight on this condition and its impact on the lives of millions of women around the world. By helping raise awareness, we hope that increased funding for research will be made available, allowing us to move closer to providing relief for 190 million women who suffer from this debilitating disease.

At ENDOSURE, INC. we are committed to this cause, Doctors tell us that our revolutionary test can play a significant role in early diagnosis of endometriosis in a cost effective manner. By doing so, they can discover the disease at earlier stages, thereby providing early treatment options to help minimize disease progression and improve the lives of millions of women.

This week, we are excited to announce that the EndoSure family has grown with the addition of new distributors on both sides of the Atlantic, reflecting the global scale of this problem. We are delighted to announce we will be at the upcoming World Congress on Endometriosis (WCE), to be held in Edinburgh from 3 to 6 May of 2023.

We believe that our presence at this important event will be an opportunity to showcase the EndoSure Test, and to connect with others who share our passion for improving the lives of women with endometriosis. We are pleased to - offer a diagnostic option for this community, and to continue to push for progress in the fight against endometriosis.

But by working together, raising awareness, and introducing this innovative diagnostic test, we can make a real difference.

This Endometriosis Awareness Month, let's keep the conversation going and keep fighting for a brighter future for women with endometriosis.

... it's about time.

Empowerment through Endo Diagnosis

mark2112rogers@yahoo.com (Mark Rogers) — Mon, 06 Mar 2023 11:59:04 GMT

With the EndoSure test, we can offer hope and empowerment to women living with endometriosis.

Endometriosis affects millions of women worldwide, with estimates suggesting that up to 10% of women of reproductive age may have the condition. Despite this, endometriosis remains a difficult condition to diagnose, often leaving women struggling with debilitating pain and other symptoms for years before receiving a proper diagnosis.

One of the main reasons that endometriosis is so difficult to diagnose is because its symptoms can vary greatly from person to person. While some women may experience severe pain, others may have no symptoms at all. This can make it difficult for doctors to identify the condition and distinguish it from other causes of pelvic pain. In addition, the gold standard for diagnosis, laparoscopic surgery, can be expensive, invasive, and carry risks.

The psychological effects of having undiagnosed pain and being dismissed by doctors can be devastating. Women with endometriosis may feel frustrated, helpless, and isolated, and may even start to question their own experiences and sanity. This can lead to depression, anxiety, and other mental health issues, which can further exacerbate the physical symptoms of the condition.

So, what is the benefit of being diagnosed with endometriosis when there is no cure? Despite the lack of a cure, a proper diagnosis can be life-changing for women with endometriosis. It can provide validation for their experiences, help them access appropriate treatment and management options, and offer a sense of control and empowerment over their own bodies and health.

This is where the EndoSure test comes in. Our Endo test is a non-invasive diagnostic tool that can provide accurate and immediate results for endometriosis, without the need for surgery. This revolutionary technology can provide women with the validation, treatment options, and sense of control they need to manage their condition effectively.

This Endometriosis Awareness Month, let us continue to raise awareness about this condition and advocate for better diagnostic tools and treatment options. With the EndoSure test, we can offer hope and empowerment to women living with endometriosis, and work towards a future where no woman has to suffer in silence ... it's about time.

A Breakthrough in Endometriosis Testing

Wed, 30 Nov 2022 15:24:59 GMT

“I hope you have enjoyed this initial installment of the blog section of the website. Please return frequently as we explore together this complex disease as we move closer and closer to finding new therapeutics and even a cure. I hope to be able to provide you with highlights from the literature and practice as well as a window on exciting new developments coming so on!”

As a physician, maximizing patient health has been my life’s focus. My true passion, however, has always been to invent disruptive technology to expand the frontiers of medical care and enhance patient outcomes.

The moment I unlocked the medical advancement that allowed the discovery of the unique myoelectrical fingerprint of endometriosis, I knew that it would be a game changer for women everywhere.

The effect on me was both humbling and profoundly exhilarating as well as energizing. I hope you have enjoyed this initial installment of the Endometriosis blog section of the website. Please return frequently as we explore together this complex disease, endometriosis, and move closer and closer to finding new therapeutics and even a cure. I hope to be able to provide you with highlights from the literature and practice as well as a window on exciting new developments coming soon!”

EndoSure Endometriosis Blog

ENDOSURE, INC. Announces Development of @Home Version of Award Winning ENDOSURE TEST

The technology, developed by the 3CPM Company, was one of four finalists to win the National Institute of Health’s RADx Tech ACT ENDO Challenge.

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3CPM Granted Award from National Institutes of Health RADx Tech ACT ENDO Challenge

3CPM, the company responsible for helping develop the non-invasive ENDOSURE TEST for endometriosis, has received the midterm award in the National Institutes of Health (NIH) RADx Tech ACT ENDO Challenge to further develop our Tier-1 technology for at-home endometriosis diagnosis.

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ENDOSURE TEST Declared a Revolutionary Diagnostic Tool in the Battle against Endometriosis

Undiagnosed Endometriosis: The Hidden Risk of Pregnancy Complications

Women with endometriosis are known to have substantially higher pregnancy and postpartum complications, yet many are unaware of the hidden danger.

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The Alarming Connection Between Endometriosis and Pregnancy Complications

The Challenge of Asymptomatic Endometriosis

How Diagnostic Testing for Endo Can Help Prevent Pregnancy Complications

Raising Awareness: A Call to Action

Conclusion

Learn More about the ENDOSURE TEST

Adolescent Endometriosis: Why It's Underdiagnosed and How You Can Advocate for Timely Diagnosis

The earliest signs of endometriosis often present much earlier than adulthood.

Why Is Endometriosis Underdiagnosed in Adolescent Women?

Lack of Education

Diagnostic Limitations

Marginalized, Ignored, and Silenced

Know the Warning Signs of Adolescent Endometriosis

One Teen's Journey to Relief after Endometriosis Diagnosis

A New Era of Diagnostic Testing

How to Advocate for Timely Diagnosis

Conclusion

Diagnostic Testing for Endometriosis: Finally, a Tier-1 Diagnostic Test

The ENDOSURE TEST is the first and only Tier-1 diagnostic test for endometriosis.

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What Is a Tier-1 Diagnostic Test?

Three Tiers of Diagnostic Tests

A Call for a New Diagnostic Framework for Endometriosis

Tier-2 Imaging Tests Limitations

Tier-3 Diagnostic Laparoscopic Surgery Limitations

Why a Tier-1 Diagnostic Test for Endometriosis Is Critically Important

The ENDOSURE TEST: A Tier-1 Diagnostic Test for Endometriosis

Conclusion

EndoSure Announces a New Strategic Alliance with Maipl Therapeutics, Inc.

MAIPL THERAPEUTICS, INC. FORMS STRATEGIC ALLIANCE WITH ENDOSURE, INC. TO FACILITATE FIRST‑IN‑HUMAN TRIAL OF NOVEL NON‑HORMONAL ENDOMETRIOSIS THERAPY

Understanding Endometriosis: A Detailed Look at Common Symptoms

How Pelvic Physiotherapy Helps Relieve Endo Pain

Physical therapy is a powerful treatment option for some patients who may be considering surgery for relief from endometriosis symptoms.

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What Is Pelvic Physiotherapy?

How to Access a Pelvic Physiotherapist

Pelvic Physiotherapy for Patients with Endometriosis

Benefits of Pelvic Physiotherapy for Patients with Dyspareunia

Benefits of Pelvic Physiotherapy for Patients with Adhesions

For Patients without an Endometriosis Diagnosis: The ENDOSURE TEST Fills the Gap

Pelvic Physiotherapy as a Treatment Alternative to Surgery for Select Patients

Daily Function Value

Post Surgical Value

What Newly Diagnosed Endometriosis Patients Should Know

How Soon Should Patients Seek Pelvic Physiotherapy?

Is There an Age Limit for Pelvic Physiotherapy?

What to Expect at the First Appointment

Conclusion

Endometriosis: A New Era in Diagnostics

Laparoscopic surgery is no longer the only way to diagnose endometriosis. There is now a new breakthrough endo test on the horizon.

How has Endometriosis Typically Been Diagnosed?

Endometriosis is typically diagnosed through a combination of medical history, physical examination, imaging, and sometimes surgical procedures. Below is a a step-by-step breakdown of how diagnosis usually occurs.

Bringing Hope During Endometriosis Awareness Month

Early Diagnosis leads to better Patient Outcomes | Endosure

Empowerment through Endo Diagnosis

With the EndoSure test, we can offer hope and empowerment to women living with endometriosis.

A Breakthrough in Endometriosis Testing